Article
Oxidative damage and mitochondrial decay in aging.
Proceedings of the National Academy of Sciences of the United States of America - 8 Nov 1994
Shigenaga M K, Hagen T M, Ames B N
Abstract excerpt
We argue for the critical role of oxidative damage in causing the mitochondrial dysfunction of aging. Oxidants generated by mitochondria appear to be the major source of the oxidative lesions that accumulate with age. Several mitochondrial functions decline with age. The contributing factors include the intrinsic rate of proton leakage across the inner mitochondrial membrane (a correlate of oxidant formation),...
Topics
- Aging
- Animals
- DNA, Mitochondrial
- Electron Transport
- Energy Metabolism
- Humans
- Hydrogen Peroxide
- Immune System
- Intracellular Membranes
- Lipids
- Longevity
- Mitochondria