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Article

A mutational analysis of the ColE1-encoded cell cycle regulator Rcd confirms its role in plasmid stability.

Plasmid - 1 Jul 2006

Balding Claire, Blaby Ian, Summers David

Abstract excerpt

Multimers of multicopy plasmids cause instability. They arise by homologous recombination and accumulate by over-replication in a process known as the dimer catastrophe. Dimers are resolved to monomers by site-specific recombination systems such as Xer-cer of plasmid ColE1. In addition, the Rcd checkpoint hypothesis proposes that a short transcript (Rcd) coded within ColE1 cer delays the division of...

Topics

Bacterial Proteins
Base Sequence
Binding Sites
Cell Cycle
DNA Mutational Analysis
DNA Replication
DNA, Bacterial
Dimerization
Escherichia coli Proteins
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

Plasmids

Recombination, Genetic

Source

Identifiers

PMID: 16442621
DOI: 10.1016/j.plasmid.2005.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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