Article
Mutations in the gyrA and gyrB genes of fluoroquinolone-resistant Mycobacterium tuberculosis from TB patients in Thailand.
The Southeast Asian journal of tropical medicine and public health - 1 Jan 2005
Pitaksajjakul Pannamthip, Wongwit Waranya, Punprasit Wantanee, Eampokalap Boonchuy, Peacock Sharon, Ramasoota Pongrama
Abstract excerpt
Among fluoroquinolone-resistant Mycobacterium tuberculosis (FQr-MTB) isolates, mutation at positions 90, 91, and 94 in gyrA gene and at positions 495, 516, and 533 in gyrB gene have been frequently reported. In this study, 35 isolates of FQr-MTB were collected from Siriraj Hospital and Chest Disease Institute. The quinolone-resistance-determining regions (QRDR) of gyrA and gyrB genes in all 35 FQr-MTB isolates...
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