Article
Inactivation of the Na-Cl co-transporter (NCC) gene is associated with high BMD through both renal and bone mechanisms: analysis of patients with Gitelman syndrome and Ncc null mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2005
Nicolet-Barousse Laurence, Blanchard Anne, Roux Christian, Pietri Laurence, Bloch-Faure May, Kolta Sami, Chappard Christine, Geoffroy Valérie, Morieux Caroline, Jeunemaitre Xavier, Shull Gary E, Meneton Pierre, Paillard Michel, Houillier Pascal, De Vernejoul Marie-Christine
Abstract excerpt
UNLABELLED: Chronic thiazide treatment is associated with high BMD. We report that patients and mice with null mutations in the thiazide-sensitive NaCl cotransporter (NCC) have higher renal tubular Ca reabsorption, higher BMD, and lower bone remodeling than controls, as well as abnormalities in Ca metabolism, mainly caused by Mg depletion. INTRODUCTION: Chronic thiazide treatment decreases urinary Ca excretion...
Topics
- Adolescent
- Adult
- Age Factors
- Aged
- Animals
- Benzothiadiazines
- Body Weight
- Bone Density
- Bone and Bones