Article
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.
Human molecular genetics - 1 Feb 2008
Kirov George, Gumus Dilihan, Chen Wei, Norton Nadine, Georgieva Lyudmila, Sari Murat, O'Donovan Michael C, Erdogan Fikret, Owen Michael J, Ropers Hans-Hilger, Ullmann Reinhard
Abstract excerpt
Copy number variations (CNVs) account for a substantial proportion of human genomic variation, and have been shown to cause neurodevelopmental disorders. We sought to determine the relevance of CNVs to the aetiology of schizophrenia (SZ). Whole-genome, high-resolution, tiling path BAC array comparative genomic hybridization (array CGH) was employed to test DNA from 93 individuals with DSM-IV SZ. Common DNA copy...
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