Article
ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability.
PloS one - 1 Jan 2013
Errami Youssef, Brim Hassan, Oumouna-Benachour Karine, Oumouna Mustapha, Naura Amarjit S, Kim Hogyoung, Ju Jihang, Davis Christian J, Kim Jong G, Ashktorab Hassan, Fallon Kenneth, Xu Ming, Zhang Jianhua, Del Valle Luis, Boulares A Hamid
Abstract excerpt
We previously showed that DNA fragmentation factor, which comprises a caspase-3-activated DNase (CAD) and its inhibitor (ICAD), may influence the rate of cell death by generating PARP-1-activating DNA breaks. Here we tested the hypothesis that ICAD-deficient colon epithelial cells exhibiting resi...
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