Article
Altered cardiac metabolic phenotype after prolonged inhibition of NO synthesis in chronically instrumented dogs.
American journal of physiology. Heart and circulatory physiology - 1 Apr 2006
d'Agostino Chiara, Labinskyy Volodymyr, Lionetti Vincenzo, Chandler Margaret P, Lei Biao, Matsuo Ken, Bellomo Michelle, Xu Xiaobin, Hintze Thomas H, Stanley William C, Recchia Fabio A
Abstract excerpt
Acute inhibition of nitric oxide (NO) synthase causes a reversible alteration in myocardial substrate metabolism. We tested the hypothesis that prolonged NO synthase inhibition alters cardiac metabolic phenotype. Seven chronically instrumented dogs were treated with N(omega)-nitro-L-arginine methyl ester (L-NAME, 35 mg.kg(-1).day(-1) po) for 10 days to inhibit NO synthesis, and seven were used as controls....
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