The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men.

doi:10.1016/j.lfs.2005.12.030

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Article

The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men.

Life sciences - 30 May 2006

Pivac Nela, Knezevic Jelena, Mustapic Maja, Dezeljin Martina, Muck-Seler Dorotea, Kozaric-Kovacic Dragica, Balija Melita, Matijevic Tanja, Pavelic Jasminka

Abstract excerpt

Monoamine oxidase (MAO), a mitochondrial flavine containing enzyme, exists in two isoenzymes, MAO-A and MAO-B. Platelets contain MAO-B subtype, proposed to be a biomarker for different personality characteristics and vulnerability for substance abuse. The most common polymorphism of MAO-B gene, a single base change (A or G) occurs in intron 13. It has been proposed to be a functional polymorphism, controlling the...

Topics

Adult
Blood Platelets
Croatia
DNA
Genotype
Humans
Introns
Male
Middle Aged
Monoamine Oxidase
Polymorphism, Genetic
Smoking
Transcription Factor AP-2

Source

Open in PubMed

Identifiers

PMID: 16427095
DOI: 10.1016/j.lfs.2005.12.030

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