Article
Association of A/G polymorphism in intron 13 of the monoamine oxidase B gene with schizophrenia in a Spanish population.
Neuropsychobiology - 1 Jan 2008
Gassó Patricia, Bernardo Miquel, Mas Sergi, Crescenti Anna, Garcia Clemente, Parellada Eduard, Lafuente Amalia
Abstract excerpt
BACKGROUND: Monoamine oxidase B (MAO-B) enzyme is involved in the oxidative metabolism of dopamine. We studied whether the A644G polymorphism in intron 13 of the MAO-B gene is a risk factor for schizophrenia. METHODS: 242 subjects diagnosed with schizophrenia and related disorders and 290 hospital-based controls participated in the study. Genomic DNA was isolated from whole blood and genotyped with the...
Topics
- Adult
- Aged
- Chi-Square Distribution
- DNA Mutational Analysis
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Introns
- Male
- Middle Aged
- Monoamine Oxidase
- Multivariate Analysis