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Disulfiram irreversibly aggregates betaine aldehyde dehydrogenase--a potential target for antimicrobial agents against Pseudomonas aeruginosa.

Biochemical and biophysical research communications - 10 Mar 2006

Velasco-García Roberto, Zaldívar-Machorro Víctor J, Mújica-Jiménez Carlos, González-Segura Lilian, Muñoz-Clares Rosario A

Abstract excerpt

In the human pathogen Pseudomonas aeruginosa, betaine aldehyde dehydrogenase (PaBADH) may play the dual role of assimilating carbon and nitrogen from choline or choline precursors--abundant at infection sites--and producing glycine betaine, which protects the bacterium against the high-osmolality stress prevalent in the infected tissues. This tetrameric enzyme contains four cysteine residues per subunit and is a...

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PMID: 16426571
DOI: 10.1016/j.bbrc.2006.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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