Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Choline catabolism to glycine betaine contributes to Pseudomonas aeruginosa survival during murine lung infection.

PloS one - 1 Jan 2013

Wargo Matthew J

Abstract excerpt

Pseudomonas aeruginosa can acquire and metabolize a variety of molecules including choline, an abundant host-derived molecule. In P. aeruginosa, choline is oxidized to glycine betaine which can be used as an osmoprotectant, a sole source of carbon and nitrogen, and as an inducer of the virulence factor, hemolytic phospholipase C (PlcH) via the transcriptional regulator GbdR. The primary objective was to determine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Oxidoreductases
Share to Betaine
Share to Choline

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Pseudomonas aeruginosa

Share to Pseudomonas Infections

Share to Transferases (Other Substituted Phosphate Groups)

Source

Open in PubMed Open full text

Identifiers

PMID: 23457628
DOI: 10.1371/journal.pone.0056850
PMCID: PMC3572970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Choline catabolism to glycine betaine contributes to Pseudomonas aeruginosa survival during murine lung infection.PMID 23457628Read ↗

A genome-wide screen in <i>Pseudomonas aeruginosa</i> identifies genes impacting production of the hemolytic phospholipase C/sphingomyelinase, PlcHSemantic proximity Read ↗

<i>Pseudomonas aeruginosa</i> LasR-deficient mutants have increased methylglyoxal and hydrogen peroxide sensitivity due to low intracellular glutathioneSemantic proximity Read ↗

Disulfiram irreversibly aggregates betaine aldehyde dehydrogenase--a potential target for antimicrobial agents against Pseudomonas aeruginosa.Semantic proximity Read ↗

Uncoupling of choline-O-sulphate utilization from osmoprotection in Pseudomonas putida.Semantic proximity Read ↗

Presence of a gene encoding choline sulfatase in Sinorhizobium meliloti bet operon: choline-O-sulfate is metabolized into glycine betaine.Semantic proximity Read ↗

Glycine betaine transmethylase mutant of Pseudomonas aeruginosa.Semantic proximity Read ↗

Blocking phosphatidylcholine utilization in Pseudomonas aeruginosa, via mutagenesis of fatty acid, glycerol and choline degradation pathways, confirms the importance of this nutrient source in vivo.Semantic proximity Read ↗

The Sinorhizobium meliloti glycine betaine biosynthetic genes (betlCBA) are induced by choline and highly expressed in bacteroids.Semantic proximity Read ↗

Absence of membrane phosphatidylcholine does not affect virulence and stress tolerance phenotypes in the opportunistic pathogen Pseudomonas aeruginosa.Semantic proximity Read ↗

Differential requirements for processing and transport of short-chain versus long-chain O-acylcarnitines in Pseudomonas aeruginosa.Semantic proximity Read ↗

Sarcosine Catabolism in Pseudomonas aeruginosa Is Transcriptionally Regulated by SouR.Semantic proximity Read ↗

Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.