Article
Collagen dysregulation in the dermis of the Sagg/+ mouse: a loose skin model.
The Journal of investigative dermatology - 1 Mar 2006
Christner Paul J, Gentiletti Julieta, Peters Josephine, Ball Simon T, Yamauchi Mitsuo, Atsawasuwan Phimon, Beason David P, Soslowsky Louis J, Birk David E
Abstract excerpt
The Sagg/+ mouse is an ethylnitrosourea-derived mutant with a dermal phenotype similar to some of the subtypes of Ehlers-Danlos syndrome (EDS) and cutis laxa. The dermis of the Sagg/+ mouse has less dense and more disorganized collagen fibers compared to controls. The size of extracted Type I dermal collagen was the same as that observed in normal skin; however, more collagen could be extracted from Sagg/+ skin,...
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