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Article

Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure.

PloS one - 1 Jan 2017

Maccarana Marco, Svensson René B, Knutsson Anki, Giannopoulos Antonis, Pelkonen Mea, Weis MaryAnn, Eyre David, Warman Matthew, Kalamajski Sebastian

Abstract excerpt

The main structural component of connective tissues is fibrillar, cross-linked collagen whose fibrillogenesis can be modulated by Small Leucine-Rich Proteins/Proteoglycans (SLRPs). Not all SLRPs' effects on collagen and extracellular matrix in vivo have been elucidated; one of the less investigated SLRPs is asporin. Here we describe the successful generation of an Aspn-/- mouse model and the investigation of the...

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Identifiers

PMID: 28859141
DOI: 10.1371/journal.pone.0184028
PMCID: PMC5578652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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