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Article

Genetic Associations of Plasminogen Activator Inhibitor-1-Related miRNA Variants with Coronary Artery Disease.

International journal of molecular sciences - 27 Oct 2024

Ha Yong Hyun, Sung Jung Hoon, Ryu Chang Soo, Ko Eun Ju, Park Hyeon Woo, Park Han Sung, Kim Ok Joon, Kim In Jai, Kim Nam Keun

Abstract excerpt

Coronary artery disease (CAD) is one of the most common types of cardiovascular disease and can lead to a heart attack as plaque gradually builds up inside the coronary arteries, blocking blood flow. Previous studies have shown that polymorphisms in the PAI-1 gene are associated with CAD; however, studies of the PAI-1 3'-untranslated region, containing a miRNA binding site, and the miRNAs that interact with it,...

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PMID: 39519081
DOI: 10.3390/ijms252111528
PMCID: PMC11546797

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