Deficiency of Mannose-Binding Lectin Greatly Increases Susceptibility to Postburn Infection with <i>Pseudomonas aeruginosa</i>

Abstract excerpt

Burn injury disrupts the mechanical and biological barrier that the skin presents against infection by symbionts like the Pseudomonas aeruginosa, a Gram-negative bacteria. A combination of local factors, antimicrobial peptides, and resident effector cells form the initial response to mechanical injury of the skin. This activity is followed by an inflammatory response that includes influx of phagocytes and serum...

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