Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurogenin1 effectively reprograms cultured chick retinal pigment epithelial cells to differentiate toward photoreceptors.

The Journal of comparative neurology - 15 Feb 2010

Yan Run-Tao, Liang Lina, Ma Wenxin, Li Xiumei, Xie Wenlian, Wang Shu-Zhen

Abstract excerpt

Photoreceptors are highly specialized sensory neurons in the retina, and their degeneration results in blindness. Replacement with developing photoreceptor cells promises to be an effective therapy, but it requires a supply of new photoreceptors, because the neural retina in human eyes lacks rege...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Signaling
Share to Chick Embryo
Share to Light Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurogenesis

Share to Photoreceptor Cells, Vertebrate

Share to Retinal Pigment Epithelium

Share to Rod Opsins

Share to Transducin

Source

Open in PubMed Open full text

Identifiers

PMID: 20029995
DOI: 10.1002/cne.22236
PMCID: PMC2927132

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20029995-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurogenin1 effectively reprograms cultured chick retinal pigment epithelial cells to differentiate toward photoreceptors.PMID 20029995Read ↗

Loss of NR2E3 disrupts rod photoreceptor cell maturation causing a fate switch late in human retinal developmentSemantic proximity Read ↗

Specific photoreceptor cell fate pathways are differentially altered in NR2E3-associated diseasesSemantic proximity Read ↗

AAV-mediated generation of neurons in injury-induced and inherited retinal degenerationsSemantic proximity Read ↗

Stimulating neurogenesis of distinct retinal lineages in human retinal pigmented epithelium (RPE) with proneural transcription factorsSemantic proximity Read ↗

Iris-derived cells from adult rodents and primates adopt photoreceptor-specific phenotypes.Semantic proximity Read ↗

Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursors.Semantic proximity Read ↗

Master control genes in the regeneration of rod photoreceptors from endogenous progenitor cells in zebrafish retinaSemantic proximity Read ↗

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal developmentSemantic proximity Read ↗

Activation of rod input in a model of retinal degeneration reverses retinal remodeling and induces formation of normal synapses, circuitry and visual signaling in the adult retinaSemantic proximity Read ↗

IDENTIFICATION OF HUMAN PHOTORECEPTORS SUITABLE FOR CELL REPLACEMENT STUDIES IN A PRECLINICAL ACHROMATOPSIA MODELSemantic proximity Read ↗

Regeneration of Functional Retinal Ganglion Cells by Neuronal Identity ReprogrammingSemantic proximity Read ↗

Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor TransplantationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.