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The Papillomavirus E1 Helicase Activates a Cellular DNA Damage Response in Viral Replication Foci

7 Jul 2011

Abstract excerpt

The papillomavirus E1 and E2 proteins are essential for viral genome replication. E1 is a helicase that unwinds the viral origin and recruits host cellular factors to replicate the viral genome. E2 is a transcriptional regulator that helps recruit the E1 helicase to the origin and also plays a role in genome partitioning. We find that when coexpressed, the E1 and E2 proteins from several papillomavirus types...

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PMID: 21734054
DOI: 10.1128/jvi.00541-11

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