Article
Tumors driven by RAS signaling harbor a natural vulnerability to oncolytic virus M1.
Molecular oncology - 1 Dec 2020
Cai Jing, Lin Kaiying, Cai Wei, Lin Yuan, Liu Xincheng, Guo Li, Zhang Jifu, Xu Wencang, Lin Ziqing, Wong Chun Wa, Sander Max, Hu Jun, Yan Guangmei, Zhu Wenbo, Liang Jiankai
Abstract excerpt
Oncolytic viruses are potent anticancer agents that replicate within and kill cancer cells rather than normal cells, and their selectivity is largely determined by oncogenic mutations. M1, a novel oncolytic virus strain, has been shown to target cancer cells, but the relationship between its cancer selectivity and oncogenic signaling pathways is poorly understood. Here, we report that RAS mutation promotes the...
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