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Article

Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.

Clinical pharmacology and therapeutics - 1 Jan 2006

Lötsch Jörn, Skarke Carsten, Wieting Johannes, Oertel Bruno Georg, Schmidt Helmut, Brockmöller Jürgen, Geisslinger Gerd

Abstract excerpt

AIM: Our aim was to judge the importance of candidate pharmacogenetic modulators of the central nervous effects of levomethadone by both magnitude of the modulatory effect and frequency of the mutation to assess the utility of genotyping for clinical levomethadone therapy in a random sample of subjects that, by distribution of genotypes, resembled the clinical setting. METHODS: Candidate pharmacogenetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16413243
DOI: 10.1016/j.clpt.2005.09.010

Genes

OPRM1
ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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