Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Splice-correction strategies for treatment of X-linked agammaglobulinemia.

Current allergy and asthma reports - 1 Mar 2015

Bestas Burcu, Turunen Janne J, Blomberg K Emelie M, Wang Qing, Månsson Robert, El Andaloussi Samir, Berglöf Anna, Smith C I Edvard

Abstract excerpt

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disease caused by mutations in the gene coding for Bruton's tyrosine kinase (BTK). Deficiency of BTK leads to a developmental block in B cell differentiation; hence, the patients essentially lack antibody-producing plasma cells and a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agammaglobulinaemia Tyrosine Kinase
Share to Agammaglobulinemia
Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Diseases, X-Linked

Share to Mutation

Share to Protein-Tyrosine Kinases

Share to RNA, Messenger

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 25638286
DOI: 10.1007/s11882-014-0510-0
PMCID: PMC4312560

Genes

BTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25638286-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Splice-correction strategies for treatment of X-linked agammaglobulinemia.PMID 25638286Read ↗

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia modelSemantic proximity Read ↗

Splice-switching antisense oligonucleotides as therapeutic drugsSemantic proximity Read ↗

Expansion of Splice-Switching Therapy with Antisense OligonucleotidesSemantic proximity Read ↗

Optimizing Integration and Expression of Transgenic Bruton's Tyrosine Kinase for CRISPR-Cas9-Mediated Gene Editing of X-Linked Agammaglobulinemia.Semantic proximity Read ↗

Splicing modulation therapy in the treatment of genetic diseasesSemantic proximity Read ↗

RNA Splicing Manipulation: Strategies to Modify Gene Expression for a Variety of Therapeutic OutcomesSemantic proximity Read ↗

RNA-targeted splice-correction therapy for neuromuscular diseaseSemantic proximity Read ↗

Genetic therapies for RNA mis-splicing diseases.Semantic proximity Read ↗

Development of Therapeutic Splice-Switching OligonucleotidesSemantic proximity Read ↗

Molecular correction of Duchenne muscular dystrophy by splice modulation and gene editing.Semantic proximity Read ↗

Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in manSemantic proximity Read ↗

Hematopoietic stem cell gene editing rescues B-cell development in X-linked agammaglobulinemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.