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Article

Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia.

Leukemia - 1 Oct 2012

Swords R, Freeman C, Giles F

Abstract excerpt

Acute myeloid leukemia (AML) is a highly heterogenous disease with multiple signaling pathways contributing to its pathogenesis. A key driver of AML is the FMS-like tyrosine kinase receptor-3 (FLT3). Activating mutations in FLT3, primarily the FLT3-internal tandem duplication (FLT3-ITD), are associated with decreased progression-free and overall survival. Identification of the importance of FLT3-ITD and the FLT3...

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Source

Identifiers

PMID: 22614177
DOI: 10.1038/leu.2012.114

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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