Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia.

Leukemia - 1 Oct 2012

Swords R, Freeman C, Giles F

Abstract excerpt

Acute myeloid leukemia (AML) is a highly heterogenous disease with multiple signaling pathways contributing to its pathogenesis. A key driver of AML is the FMS-like tyrosine kinase receptor-3 (FLT3). Activating mutations in FLT3, primarily the FLT3-internal tandem duplication (FLT3-ITD), are associated with decreased progression-free and overall survival. Identification of the importance of FLT3-ITD and the FLT3...

Topics

Benzenesulfonates
Benzothiazoles
CCAAT-Enhancer-Binding Protein-alpha
Carbazoles
Furans
Humans
Leukemia, Myeloid, Acute
Mutation
Niacinamide
Phenylurea Compounds
Prognosis
Pyridines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sorafenib

Staurosporine

fms-Like Tyrosine Kinase 3

Source

Identifiers

PMID: 22614177
DOI: 10.1038/leu.2012.114

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22614177-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia.PMID 22614177Read ↗

Fms -like tyrosine kinase 3 positive acute myeloid leukemia.Semantic proximity Read ↗

FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions.Semantic proximity Read ↗

Tyrosine kinase inhibitors targeting FLT3 in the treatment of acute myeloid leukemiaSemantic proximity Read ↗

Targeting FLT3 Mutations in Acute Myeloid LeukemiaSemantic proximity Read ↗

Targeting FMS-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia: Novel molecular approaches and therapeutic challengesSemantic proximity Read ↗

FLT3 targeting in the modern era: from clonal selection to combination therapies.Semantic proximity Read ↗

FLT3-targeted treatment for acute myeloid leukemia.Semantic proximity Read ↗

FLT3 inhibitors in the treatment of acute myeloid leukemia: current status and future perspectives.Semantic proximity Read ↗

Targeting FLT3 to treat leukemia.Semantic proximity Read ↗

FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia.Semantic proximity Read ↗

Recent Advances in FLT3 Inhibitors for Acute Myeloid LeukemiaSemantic proximity Read ↗

Potential targeting of FLT3 acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.