FLT3 signaling and the development of inhibitors that target FLT3 kinase activity.

doi:10.1615/critrevoncog.v17.i2.50

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Article

FLT3 signaling and the development of inhibitors that target FLT3 kinase activity.

Critical reviews in oncogenesis - 1 Jan 2012

Langdon Wallace Y

Abstract excerpt

The FMS-like receptor tyrosine kinase-3 (FLT3) plays a key role in hematopoietic development and is frequently mutated in patients with acute myeloid leukemia (AML). These mutations render FLT3 constitutively active, and patients harboring these mutations have a poor prognosis. Targeting the kina...

Topics

Animals
Antineoplastic Agents
Disease Models, Animal
Humans
Leukemia, Myeloid, Acute
Mice
Mutation
Protein Kinase Inhibitors
Signal Transduction
fms-Like Tyrosine Kinase 3

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