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Evidence of a high proportion of premature unbalanced separation of sister chromatids in the first polar bodies of women of advanced age

12 Jan 2006

Abstract excerpt

BACKGROUND: Maternal ageing is the only aetiological factor unequivocally linked to aneuploidy. Two mechanisms seem to explain these abnormalities in oocytes: non-disjunction and premature unbalanced separation of sister chromatids (PSSC). Previous studies of unfertilized oocytes argue for a major role of PSSC in the aetiology of aneuploidy for women of advanced age, but in vitro ageing of the oocytes could...

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PMID: 16410329
DOI: 10.1093/humrep/dei484

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