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Article

Sequential FISH analysis of oocytes and polar bodies reveals aneuploidy mechanisms

14 Jul 2003

Abstract excerpt

OBJECTIVES: Constitutional aneuploidy occurs in at least 5% of recognised pregnancies, with apparent preferential involvement of the X chromosome and the smaller autosomes. Molecular cytogenetic investigations of cleavage-stage embryos have revealed anomalies affecting all sizes of chromosomes. The aim was to investigate the variety of anomalies arising during maternal meiosis I by analysis of unfertilised...

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PMID: 12913873
DOI: 10.1002/pd.665

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