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Comparative genomic hybridization analysis of human oocytes and polar bodies

17 May 2006

Abstract excerpt

BACKGROUND: Classical cytogenetic methods and fluorescent in situ hybridization (FISH) have been employed for the analysis of chromosomal abnormalities in human oocytes. However, these methods are limited by the need to spread the sample on a microscope slide, a process that risks artefactual chromosome loss. Comparative genomic hybridization (CGH) is a DNA-based method that enables the investigation of the...

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Share to Chromosomal and Genetic Variations
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PMID: 16704993
DOI: 10.1093/humrep/del157

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