Article
Localization of a susceptibility locus for hepatocellular carcinoma to chromosome 4q in a hepatitis B hyperendemic area.
Oncogene - 25 May 2006
Shih W-L, Yu M-W, Chen P-J, Yeh S-H, Lo M-T, Chang H-C, Liaw Y-F, Lin S-M, Liu C-J, Lee S-D, Lin C-L, Hsiao C K, Yang S-Y, Chen C-J
Abstract excerpt
Chromosome 4q is one of the most common regions with a high frequency of allelic loss in hepatocellular carcinoma (HCC). To identify the HCC-susceptibility locus on chromosome 4q, we have performed linkage and family-based association analyses on Chinese families with HCC from Taiwan, where hepatitis B is hyperendemic. Using 77 microsatellite markers spanning chromosome 4q on 52 multiplex families, we found...
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