[Genetic effects induced by nickel sulfate in germline and somatic cells of WR mice].

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Article

[Genetic effects induced by nickel sulfate in germline and somatic cells of WR mice].

Genetika - 1 Jul 2005

Domshlak M G, Elakov A L, Osipov A N

Abstract excerpt

We examined the effects of nickel sulfate at doses 0.5 to 5.0 mg/kg (LD50) on the frequency of dominant lethal mutations and two-strand DNA breaks (TSBs) in germline cells and on an increase in frequency in gene mutations W(y) in pigment cells of first-generation mice. The results indicated that spermatogenesis stages most sensitive to nickel sulfate (at a dose of 1.0 mg/kg) are spermatozoids, early spermatids,...

Topics

Animals
DNA Damage
DNA Fragmentation
Female
Genes, Dominant
Genes, Lethal
Lethal Dose 50
Male
Mice
Mice, Inbred Strains
Mutagens
Mutation
Nickel
No-Observed-Adverse-Effect Level
Spermatogenesis
Spermatozoa

Source

Open in PubMed

Identifiers

PMID: 16152793

Provenance

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