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Article

Enhanced tumorigenesis in p53 knockout mice exposed in utero to high-dose vitamin E.

Carcinogenesis - 1 Jul 2006

Chen Connie S, Wells Peter G

Abstract excerpt

The limited antioxidative capacity of the embryo and fetus may increase their risk for cancer initiation and/or promotion by reactive oxygen species (ROS)-mediated oxidative DNA damage and/or signaling. To determine if cancer can originate in utero, a high dietary dose of the antioxidant vitamin E (VE) (10% dl-alpha-tocopherol-acetate) was given to cancer-prone p53 knockout mice throughout pregnancy. Although...

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Identifiers

PMID: 16401638
DOI: 10.1093/carcin/bgi325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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