Article
17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions.
Archives of neurology - 1 Mar 2004
Wilhelmsen Kirk C, Forman Mark S, Rosen Howard J, Alving Loren I, Goldman Jill, Feiger Jennie, Lee James V, Segall Samantha K, Kramer Joel H, Lomen-Hoerth Catherine, Rankin Katherine P, Johnson Julene, Feiler Heidi S, Weiner Michael W, Lee Virginia M-Y, Trojanowski John Q, Miller Bruce L
Abstract excerpt
BACKGROUND: Frontotemporal dementia (FTD) is a clinically heterogeneous condition that can be associated with clinical manifestations of an extrapyramidal disorder or motor neuron disease. A range of histologic patterns has been described in patients with FTD. The most common familial form of this condition is caused by mutations in the microtubule-associated protein tau gene (MAP tau) and is associated with...
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