Article
Hormones are key actors in gene x environment interactions programming the vulnerability to Parkinson's disease: glia as a common final pathway.
Annals of the New York Academy of Sciences - 1 Dec 2005
Marchetti Bianca, Serra Pier Andrea, L'Episcopo Francesca, Tirolo Cataldo, Caniglia Salvo, Testa Nuccio, Cioni Serena, Gennuso Florinda, Rocchitta Gaia, Desole Maria Speranza, Mazzarino Maria Clorinda, Miele Egidio, Morale Maria Concetta
Abstract excerpt
Alterations in developmental programming of neuroendocrine and immune system function may critically modulate vulnerability to various diseases. In particular, genetic factors, including gender, may interact with early life events such as exposure to hormones, endotoxins, or neurotoxins, thereby influencing disease predisposition and/or severity, but little is known about the role of the astroglial cell...
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