Article
Susceptibility of inbred strains of mice to murine AIDS (MAIDS) correlates with target cell expansion and high expression of defective MAIDS virus.
Journal of virology - 1 Apr 1992
Huang M, Simard C, Jolicoeur P
Abstract excerpt
Murine AIDS (MAIDS) is readily induced by the Duplan strain of defective murine leukemia virus in susceptible C57BL/6 mice. To identify mouse strains resistant to MAIDS, and to understand the genetic factors controlling susceptibility to the disease, we screened more than 20 inbred strains of mic...
Topics
- 3T3 Cells
- Animals
- Blotting, Northern
- Blotting, Southern
- DNA, Viral
- Disease Susceptibility
- Female
- Genotype
- Immunization
- Leukemia Virus, Murine
- Male
- Mice
- Mice, Inbred Strains
- Murine Acquired Immunodeficiency Syndrome
- Proviruses
- RNA, Viral
- Spleen
- T-Lymphocytes