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Aspartic Acid Homozygosity at Codon 57 of HLA-DQ β Is Associated with Susceptibility to Pulmonary Tuberculosis in Cambodia

1 Jan 2006

Abstract excerpt

After infection with Mycobacterium tuberculosis, clinical disease usually remains latent, contained by the host immune response. Although polymorphisms of HLA loci have been hypothesized to play a major role in the breakdown of latency, a functional link has not been established. Molecular-based HLA-typing methods were used to test the association of sets of HLA alleles encoding an aspartic acid at codon 57 of...

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PMID: 16393997
DOI: 10.4049/jimmunol.176.2.1090

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