Article
HLA-A and HLA-DRB1 amino acid polymorphisms are associated with susceptibility and protection to pulmonary tuberculosis in a Greek population.
Human immunology - 1 Jun 2012
Magira Eleni E, Papasteriades Chryssa, Kanterakis Stathis, Toubis Michalis, Roussos Charis, Monos Dimitri S
Abstract excerpt
BACKGROUND: Pulmonary tuberculosis remains the single deadliest infectious disease causing high mortality in humans leading to 1.4 million deaths annually. Inherited genetic factors may explain why some people resist infection more successfully than others. METHODS: The polymorphisms of HLA-class I (-A, -B) and class II (-DRB1, -DQB1) genes have been evaluated using DNA-based typing in a population of 86...
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