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Article

Intestinal permeability and genetic determinants in patients, first-degree relatives, and controls in a high-incidence area of Crohn's disease in Southern Italy.

The American journal of gastroenterology - 1 Dec 2005

Fries Walter, Renda Maria C, Lo Presti Maria A, Raso Antonella, Orlando Ambrogio, Oliva Lorenzo, Giofré Maria R, Maggio Aurelio, Mattaliano Anna, Macaluso Alfredo, Cottone Mario

Abstract excerpt

OBJECTIVE: A defect of gastrointestinal barrier function is considered to represent an important step in the pathogenesis of Crohn's disease (CD) but the mechanisms leading to an increased intestinal permeability (IP) are poorly understood. Since IP is influenced by pro-inflammatory mediators, it seems likely that a genetically determined abnormal immune response may lead to a loss of barrier function. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16393227
DOI: 10.1111/j.1572-0241.2005.00325.x

Genes

NOD2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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