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Article

Repair of Articular Cartilage Defect by Intraarticular Administration of Basic Fibroblast Growth Factor Gene, Using Adeno-Associated Virus Vector

1 Dec 2005

Abstract excerpt

The objective of this study was to establish the potency of adeno-associated virus (AAV) as a viral vector to transport the basic fibroblast growth factor (bFGF) gene into synovial tissue, and to evaluate the consequent repair of articular cartilage defects. In the in vitro study, LacZ- and bFGF-encoding genes were transduced into rabbit synoviocytes by recombinant adeno-associated virus (AAV) vector, and the...

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Identifiers

PMID: 16390272
DOI: 10.1089/hum.2005.16.1413

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