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Article

Gene therapy for human osteoarthritis: principles and clinical translation

21 Nov 2015

Abstract excerpt

INTRODUCTION: Osteoarthritis (OA) is the most prevalent chronic joint disease. Its key feature is a progressive articular cartilage loss. Gene therapy for OA aims at delivering gene-based therapeutic agents to the osteoarthritic cartilage, resulting in a controlled, site-specific, long-term presence to rebuild the damaged cartilage. AREAS COVERED: An overview is provided of the principles of gene therapy for OA...

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PMID: 26593049
DOI: 10.1517/14712598.2016.1124084

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