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Article

Adeno-Associated Vector mediated gene transfer of Transforming Growth Factor -beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism

14 Nov 2005

Abstract excerpt

The objective of the present study was to investigate whether cartilage anabolism in human primary osteoarthritic chondrocytes could be improved by adeno-associated virus (AAV) vector-mediated gene transduction of transforming growth factor TGF-beta1 (TGF-beta1). A bi-cistronic AAV-TGF-beta1-IRES-eGFP (AAV-TGF-beta1) vector was generated and used for transduction of a normal human articular chondrocyte cell line...

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PMID: 16284937
DOI: 10.22203/ecm.v010a05

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