The Adeno Associated Viral Vector as a Strategy for Intradiscal Gene Transfer in Immune Competent and Pre-Exposed Rabbits

Abstract excerpt

In Brief Study Design. Experimental animal study. Objectives. This study evaluates the in vitro and in vivo transduction efficacy and transgene expression in immune competent and pre-exposed rabbits Summary of Background Data. Degenerative disc disease (DDD) continues to pose a substantial clinical problem. Therapeutic options such as an interbody fusion are highly invasive and result in the loss of the...

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