Article
Single nucleotide polymorphisms in the multidrug resistance 1 gene in Korean epileptics.
Seizure - 1 Jan 2006
Kim Young Ok, Kim Myeong Kyu, Woo Young Jong, Lee Min Cheol, Kim Jin Hee, Park Ki Won, Kim Eun Young, Roh Young Il, Kim Chan Jong
Abstract excerpt
PURPOSE: P-glycoprotein 170 encoded by the multidrug resistance 1 (MDR1) gene exports various antiepileptic drugs out of the CNS, which leads to multidrug resistance. This study was performed to elucidate the relationship between single nucleotide polymorphisms (SNPs) in the MDR1 gene and drug resistance in Koreans with epilepsy. SUBJECTS AND METHODS: Three SNPs at nucleotide position 1236 in exon 12, 2677 in...
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