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Article

Characterization of rabbit myocilin: Implications for human myocilin glycosylation and signal peptide usage.

BMC genetics - 2 Apr 2003

Shepard Allan R, Jacobson Nasreen, Sui Ruifang, Steely H Thomas, Lotery Andrew J, Stone Edwin M, Clark Abbot F

Abstract excerpt

BACKGROUND: Mutations in the gene encoding human myocilin (MYOC) have been shown to cause juvenile- and adult-onset glaucoma. In addition, myocilin has been associated with glucocorticoid-induced ocular hypertension and steroid-induced glaucoma. To better understand the role myocilin plays in steroid-induced glaucoma and open-angle glaucoma, we examined rabbit myocilin for use in the rabbit animal model of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12697062
DOI: 10.1186/1471-2156-4-5
PMCID: PMC156599

Genes

MYOC
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Characterization of rabbit myocilin: Implications for human myocilin glycosylation and signal peptide usage.PMID 12697062Read ↗

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Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulationSemantic proximity Read ↗

In vitro and in vivo study on the secretion of the Gly367Arg mutant myocilin protein.Semantic proximity Read ↗

Full-length myocilin protein is purified from mammalian cells as a dimer.Semantic proximity Read ↗

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulationSemantic proximity Read ↗

Cystatin a, a potential common link for mutant myocilin causative glaucoma.Semantic proximity Read ↗

Glaucoma-associated myocilin: a better understanding but much more to learn.Semantic proximity Read ↗

Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cellsSemantic proximity Read ↗

The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review.Semantic proximity Read ↗

Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head.Semantic proximity Read ↗

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