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Article

Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells.

Blood - 1 May 2006

Zeuner Ann, Pedini Francesca, Signore Michele, Ruscio Giusy, Messina Carlo, Tafuri Agostino, Girelli Gabriella, Peschle Cesare, De Maria Ruggero

Abstract excerpt

Polycythemia vera (PV) is a clonal myeloproliferative disorder characterized by excessive erythrocyte production. Most patients with PV harbor an activating JAK2 mutation, but the molecular links between this mutation and erythrocyte overproduction are unknown. The interaction between death receptors and their ligands contributes to the physiological regulation of erythropoiesis through the inhibition of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16384930
DOI: 10.1182/blood-2005-07-3037

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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