Article
Detection of alternatively spliced transcripts in leukemia cell lines by minisequencing on microarrays.
Clinical chemistry - 1 Feb 2006
Milani Lili, Fredriksson Mona, Syvänen Ann-Christine
Abstract excerpt
BACKGROUND: Recent genome-wide expression studies suggest that approximately 80% of the 25,000 human genes undergo alternative splicing. Alternative splicing may be associated with human diseases, particularly with cancer, but the molecular disease mechanisms are poorly understood. Convenient, novel methods for multiplexed detection of alternatively spliced transcripts are needed. METHODS: We devised a new...
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