Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single molecule profiling of alternative pre-mRNA splicing.

Science (New York, N.Y.) - 8 Aug 2003

Zhu Jun, Shendure Jay, Mitra Robi D, Church George M

Abstract excerpt

Alternative pre-messenger RNA splicing is an important mechanism for generating protein diversity and may explain in part how mammalian complexity arises from a surprisingly small complement of genes. Here, we describe "digital polony exon profiling,"a single molecule-based technology for studying complex alternative pre-messenger RNA splicing. This technology allows researchers to monitor the combinatorial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acrylamide
Share to Alternative Splicing
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic AMP Response Element-Binding Protein

Share to Hyaluronan Receptors

Share to Microtubule-Associated Proteins

Share to RNA Precursors

Share to SMN Complex Proteins

Source

Identifiers

PMID: 12907803
DOI: 10.1126/science.1085792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single molecule profiling of alternative pre-mRNA splicing.PMID 12907803Read ↗

Dissecting splicing decisions and cell-to-cell variability with designed sequence librariesSemantic proximity Read ↗

Biomedical impact of splicing mutations revealed through exome sequencing.Semantic proximity Read ↗

Detection of alternatively spliced transcripts in leukemia cell lines by minisequencing on microarrays.Semantic proximity Read ↗

RNA sequencing for the study of splicingSemantic proximity Read ↗

Use of minigene systems to dissect alternative splicing elements.Semantic proximity Read ↗

Dynamic changes in mRNA isoform usage during human retinal organoid developmentSemantic proximity Read ↗

Alternative mRNA processing sites decrease genetic variability while increasing functional diversity.Semantic proximity Read ↗

<i>Whippet</i> : an efficient method for the detection and quantification of alternative splicing reveals extensive transcriptomic complexitySemantic proximity Read ↗

Exploring Differential Exon Usage via Short- and Long-read RNA Sequencing StrategiesSemantic proximity Read ↗

Nanopore direct RNA sequencing detects differential expression between human cell populationsSemantic proximity Read ↗

Minigene reporter for identification and analysis of cis elements and trans factors affecting pre-mRNA splicing.Semantic proximity Read ↗

Nanopore sequencing of full-length <i>BRCA1</i> mRNA transcripts reveals co-occurrence of known exon skipping eventsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.