Single molecule profiling of alternative pre-mRNA splicing.

doi:10.1126/science.1085792

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Article

Single molecule profiling of alternative pre-mRNA splicing.

Science (New York, N.Y.) - 8 Aug 2003

Zhu Jun, Shendure Jay, Mitra Robi D, Church George M

Abstract excerpt

Alternative pre-messenger RNA splicing is an important mechanism for generating protein diversity and may explain in part how mammalian complexity arises from a surprisingly small complement of genes. Here, we describe "digital polony exon profiling,"a single molecule-based technology for studying complex alternative pre-messenger RNA splicing. This technology allows researchers to monitor the combinatorial...

Topics

Acrylamide
Alternative Splicing
Animals
Brain
Cell Line
Cell Line, Transformed
Cyclic AMP Response Element-Binding Protein
Exons
Humans
Hyaluronan Receptors
Mice
Microtubule-Associated Proteins
Nerve Tissue Proteins
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Protein Isoforms
RNA Precursors
RNA-Binding Proteins

Source

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Identifiers

PMID: 12907803
DOI: 10.1126/science.1085792

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