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Human Macroprolactin Displays Low Biological Activity via Its Homologous Receptor in a New Sensitive Bioassay

6 Feb 2006

Abstract excerpt

CONTEXT: Macroprolactinemia is a frequent finding in hyperprolactinemic individuals, usually without clinical impact. Data on biological activity of macroprolactin (bbPRL) are controversial and mostly based on a heterologous rat Nb2 cell bioassay. Biological activity of bbPRL observed in vitro but not in vivo may be due to its high molecular weight, preventing its passage through capillary barrier. Alternatively,...

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PMID: 16384849
DOI: 10.1210/jc.2005-1831

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