Article
Mutations of ovine and bovine placental lactogens change, in different ways, the biological activity mediated through homologous and heterologous lactogenic receptors.
The Journal of endocrinology - 1 Apr 2001
Helman D, Herman A, Paly J, Livnah O, Elkins P A, de Vos A M, Djiane J, Gertler A
Abstract excerpt
The biological activities of ovine (o) and bovine (b) placental lactogens (PLs) and their mutated analogues were compared using several binding and in vitro bioassays. In almost all cases, the biological activities of these analogues mediated through rat (r) prolactin receptor (PRLR) showed little or no change, despite a remarkable decrease in their capacity to bind to the extracellular domain of rPRLR and...
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