Article
The amino-terminal domain of bovine viral diarrhea virus Npro protein is necessary for alpha/beta interferon antagonism.
Journal of virology - 1 Jan 2006
Gil Laura H V G, Ansari Israrul H, Vassilev Ventzislav, Liang Delin, Lai Vicky C H, Zhong Weidong, Hong Zhi, Dubovi Edward J, Donis Ruben O
Abstract excerpt
The alpha/beta interferon (IFN-alpha/beta) system is the first line of defense against viral infection and a critical link between the innate and adaptive immune responses. IFN-alpha/beta secretion is the hallmark of cellular responses to acute RNA virus infections. As part of their survival strategy, many viruses have evolved mechanisms to counteract the host IFN-alpha/beta response. Bovine viral diarrhea virus...
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