Article
Analysis of a pair of END+ and END- viruses derived from the same bovine viral diarrhea virus stock reveals the amino acid determinants in Npro responsible for inhibition of type I interferon production.
The Journal of veterinary medical science - 1 May 2015
Kozasa Takashi, Abe Yuri, Mitsuhashi Kazuya, Tamura Tomokazu, Aoki Hiroshi, Ishimaru Masatoshi, Nakamura Shigeyuki, Okamatsu Masatoshi, Kida Hiroshi, Sakoda Yoshihiro
Abstract excerpt
The Exaltation of Newcastle disease virus (END) phenomenon is induced by the inhibition of type I interferon in pestivirus-infected cells in vitro, via proteasomal degradation of cellular interferon regulatory factor (IRF)-3 with the property of the viral autoprotease protein N(pro). Reportedly, the amino acid residues in the zinc-binding TRASH motif of N(pro) determine the difference in characteristics between...
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