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Article

LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer

22 Nov 2010

Abstract excerpt

BACKGROUND: Most colorectal carcinomas are driven by an activation of the canonical Wnt signalling pathway, which promotes the expression of multiple target genes mediating proliferation inavasion and invasion. Upon activation of the Wnt signalling pathway its key player β-catenin translocates from the cytoplasm to the nucleus and binds to members of the T-cell factor (TCF)/lymphoid enhancer factor (LEF-1) family...

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Share to Cancer-related gene regulation
Share to Genetic factors in colorectal cancer
Share to Wnt/β-catenin signaling in development and cancer

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PMID: 21092222
DOI: 10.1186/1479-5876-8-123

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