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Article

9α,11β‐PGF<sub>2</sub> and its stereoisomer PGF<sub>2α</sub> are novel agonists of the chemoattractant receptor, CRTH2

13 Dec 2005

Abstract excerpt

CRTH2 is a recently described chemoattractant receptor for the prostaglandin, PGD(2), expressed by Th2 cells, eosinophils and basophils, and believed to play a role in allergic inflammation. Here we describe the potency of several PGD(2) metabolites at the receptor to induce cell migration and activation. We report for the first time that the PGD(2) metabolite, 9alpha,11beta-PGF(2), and its stereoisomer,...

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Identifiers

PMID: 16378605
DOI: 10.1016/j.febslet.2005.11.052

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