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Article

Genetic linkage and association analysis for loneliness in Dutch twin and sibling pairs points to a region on chromosome 12q23-24.

Behavior genetics - 1 Jan 2006

Boomsma Dorret I, Cacioppo John T, Slagboom P Eline, Posthuma Danielle

Abstract excerpt

We obtained evidence from a large study in Dutch twins (N=8,387) and siblings (N=2,295) that variation in loneliness has a genetic component. The heritability estimate for loneliness, which was assessed as an ordinal trait, was 40% and did not differ between males and females. There were 682 sibling pairs with genotypic (around 400 microsatellite markers) data. We combined phenotypic and genotypic data to carry...

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Identifiers

PMID: 16378171
DOI: 10.1007/s10519-005-9005-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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